Part:BBa_K3117039

kappa light chain

Usage and Biology

Part BBa_K3117039 is the constant part of the light chain within an antibody. Together with the single chain variable fragment, the kappa-light chain forms the variable light chain of an antibody. Additionally, the kappa-light chain binds to the constant region 1 (BBa_K3117040) of an antibody via disulfid bonds.

MIT MAHE 2020

Summary

Kappa light chain is the constant part of the light chain within an antibody. Together with the single chain variable fragment, the kappa-light chain forms the variable light chain of an antibody. Additionally, the kappa-light chain binds to the constant region 1 of an antibody via disulfide bonds.

References

1. Vincent Rajkumar S. (2014). Multiple myeloma: 2014 Update on diagnosis, risk-stratification, and management. American journal of hematology, 89(10), 999–1009. https://doi.org/10.1002/ajh.23810

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3. Chen, J., Fang, M., Zhao, Y. P., Yi, C. H., Ji, J., Cheng, C., Wang, M. M., Gu, X., Sun, Q. S., Chen, X. L., & Gao, C. F. (2015). Serum N-Glycans: A New Diagnostic Biomarker for Light Chain Multiple Myeloma. PloS one, 10(6), e0127022. https://doi.org/10.1371/journal.pone.0127022

4. Siegel, R., Ma, J., Zou, Z., & Jemal, A. (2014). Cancer statistics, 2014. CA: a cancer journal for clinicians, 64(1), 9–29. https://doi.org/10.3322/caac.21208 "