Part:BBa_K3582004
The DBLb domain of PF11_0521 PfEMP1
This biobrick is thought to be able to produce the DBLb domain of PfEMP-1. Plasmodium falciparum erythrocyte membrane protein 1 EMP1 is encoded by the clonally variant var gene family with approximately 60 members per parasite genome. The adhesion process of the PfEMP1 proteins is often described as a way for the parasite to evade splenic clearance and has also been reported as associated with vascular obstruction of vital organs leading to major pathological events.[1]. These proteins are also known for their ability to mediate adhesion of IEs to host receptors in the vasculature.[2]
The binding of PfEMP1 to ICAM-1 is mediated by a subset of Duffy binding-like (DBL) domains, the DBLβ domains, which are found in either A-type or BC-type PfEMP1.[4][5][6][7]. The PfEMP1 protein to the D1 domain of ICAM-1[3].
Sequence and Features
- 10COMPATIBLE WITH RFC[10]
- 12COMPATIBLE WITH RFC[12]
- 21INCOMPATIBLE WITH RFC[21]Illegal BamHI site found at 1407
- 23COMPATIBLE WITH RFC[23]
- 25INCOMPATIBLE WITH RFC[25]Illegal AgeI site found at 1113
- 1000COMPATIBLE WITH RFC[1000]
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