Part:BBa_K3244015
IL-18
IL-18 cytokine for TRUCK CAR
Sequence and Features
- 10COMPATIBLE WITH RFC[10]
- 12COMPATIBLE WITH RFC[12]
- 21COMPATIBLE WITH RFC[21]
- 23COMPATIBLE WITH RFC[23]
- 25COMPATIBLE WITH RFC[25]
- 1000COMPATIBLE WITH RFC[1000]
MIT MAHE 2020
Summary
Interleukin-18 (IL-18) is a member of IL-1 family of cytokines. It is synthesized as an inactive precursor which can be processed by caspase-1 to an active cytokine. The precursor is constitutively present in nearly all cells in healthy humans and animals. Its activity is balanced by the presence of a high affinity naturally occurring IL-18 binding protein. It plays a major role in production of interferon -γ from T-cells and natural killer cells. It is said to play a part in several autoimmune diseases, myocardial function, emphysema, metabolic syndromes, psoriasis, inflammatory bowel disease, hemophagocytic syndromes, macrophage activation syndrome, sepsis, and acute kidney injury. In humans, disease severity can be associated with an imbalance of IL-18 to IL-18BP such that the levels of free IL-18 are elevated in the circulation.
References
1. Dinarello, C. A., Novick, D., Kim, S., & Kaplanski, G. (2013). Interleukin-18 and IL-18 binding protein. Frontiers in immunology, 4, 289. https://doi.org/10.3389/fimmu.2013.00289
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