Part:BBa_K3409000
Gene Product (gp) 37
Bacteriophages are viruses that can infect bacteria. Bacteriophages from Myoviridae family possesse Long Tail Fibers (LTF) which bind to specific motifs of the outer membrane of the target bacteria. T4 bacteriophages belong to Myoviridae family and are able to specifically recognize Escherichia coli thanks to specific recpetor binding proteins of the distal region of their LTF. These recpetor binding proteins recognize Lipopolysaccharide (LPS) or Outer membrane protein C which are present on the outer membrane of the target bacteria. To be more precise, the T4 uses the tip of its LTF to bind specifically to E. coli. The LTF is encoded by different proteins, on the tip is the gene product (gp) 37 and it is the gp37 that confers the T4 bacteriohage LTF binding specificity. For the proper folding of gp37, two chaperone proteins are required and have to be co-expressed, i.e., the gp 57a, encoded by the gene 57A and gp38, encoded by the gene 38. They both participate in the proper folding of the distal part of the long fibers.
Sequence and Features
- 10COMPATIBLE WITH RFC[10]
- 12COMPATIBLE WITH RFC[12]
- 21INCOMPATIBLE WITH RFC[21]Illegal BglII site found at 292
Illegal BglII site found at 1486 - 23COMPATIBLE WITH RFC[23]
- 25INCOMPATIBLE WITH RFC[25]Illegal NgoMIV site found at 1666
Illegal AgeI site found at 634 - 1000INCOMPATIBLE WITH RFC[1000]Illegal BsaI.rc site found at 1869
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