Coding

Part:BBa_K3351004

Designed by: Zizhan Tang   Group: iGEM20_NWU-CHINA-A   (2020-09-08)
Revision as of 14:26, 19 October 2020 by ZZ-NWU (Talk | contribs)


HD5, an antimicrobial peptide

Summary

A human antimicrobial peptide with 32 amino acids.HD5 fights against Gram-negative bacteria by disrupting and damaging the membrane and penetrating into the cytoplasm. Different oligomeric states were found to perform different degrees of antimicrobial activity. In solution, dimeric and tetrameric states are generally observed. A dimer was found to be the most active form, whereas a tetramer is the largest stable found in solution.
Moreover, HD5 also shows anti-endotoxin properties by binding to bacterial lipopolysaccharide (LPS) resulting in LPS neutralization. Both dimer and tetramer seem to induce the LPS membrane disruption.


Reference

[1] Awang T, Pongprayoon P. The adsorption of human defensin 5 on bacterial membranes: simulation studies. J Mol Model. 2018 Sep 5;24(10):273. doi: 10.1007/s00894-018-3812-7. PMID: 30187138. Sequence and Features


Assembly Compatibility:
  • 10
    COMPATIBLE WITH RFC[10]
  • 12
    COMPATIBLE WITH RFC[12]
  • 21
    COMPATIBLE WITH RFC[21]
  • 23
    COMPATIBLE WITH RFC[23]
  • 25
    COMPATIBLE WITH RFC[25]
  • 1000
    COMPATIBLE WITH RFC[1000]


[edit]
Categories
Parameters
None