Part:BBa_K3582012

Inhibitory Peptide sequence 1 for CD36-PfEMP CIDRa Domain Interaction

This inhibitory peptide sequence is designed using the interacting regions of CD36 protein with the CIDRa Domain of the PfEMP1 protein. This is a mutant variant of the wild type interacting sequence of the CD36 protein. The following characteristic properties are observed in the inhibitory peptide sequence: 1]Interaction Energy: - 18.8211 2]Stability Value:4.544

• Values are relative to wild type sequence.

This biobrick synthesizes the inhibitory peptide sequence that is believed to bind more efficiently as compared to the wild type sequence. The peptide sequence is built using saturated mutagenesis. In this particular mutant sequence, the last amino acid of the Wild type sequence-Serine(S) is replaced with methionine(M). As a result, an up-gradation in its interactive properties is observed that is thought to improve its binding strength.

File:Is1 BBa K3582012.png.png

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Sequence and Features

Assembly Compatibility:

• 10
  COMPATIBLE WITH RFC[10]
• 12
  COMPATIBLE WITH RFC[12]
• 21
  COMPATIBLE WITH RFC[21]
• 23
  COMPATIBLE WITH RFC[23]
• 25
  COMPATIBLE WITH RFC[25]
• 1000
  COMPATIBLE WITH RFC[1000]