Part:BBa_K3093005
HlyB
The α-hemolysin secretion pathway has mainly been reported in uropathogenic E. coli. The secretory machinery of this pathway consists of three components: HlyB, an ATP-binding cassette (ABC transporter); HlyD, a membrane fusion protein; and TolC, an outer membrane protein. HlyB and HlyD have been generally considered strain specific proteins, TolC, in contrast, is a component of multiple trans-membrane systems in many microorganisms. Thus, co-expression of HlyB/D is often performed to facilitate the extracellular translocation of proteins utilizing the α-hemolysin secretion pathway during expression in host strains other than uropathogenic E. coli.
References
[1] Vassilis Koronakis, Peter Stanley, Eva Koronakis, Colin Hughes,The HlyB/HlyD-dependent secretion of toxins by Gran-negative bacteria,FEMS Microbiology Letters,Volume 105, Issues 1–3,1992,Pages 45-53,ISSN 0378-1097.
Sequence and Features
- 10COMPATIBLE WITH RFC[10]
- 12COMPATIBLE WITH RFC[12]
- 21COMPATIBLE WITH RFC[21]
- 23COMPATIBLE WITH RFC[23]
- 25COMPATIBLE WITH RFC[25]
- 1000COMPATIBLE WITH RFC[1000]
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