Coding
Part:BBa_K3117034
Designed by: Lena Schorr Group: iGEM19_FAU_Erlangen (2019-10-18)
scFv VH sequence of anti-GPA33 antibody codon optimized for expression in E.coli
The single chain variable fragment of the heavy chain of anti-GPA33 targets the colon cancer surface marker GPA33. Glycoprotein A33 (GPA33) is a well-known surface marker of colon cancer. Under healthy conditions GPA33 is just expressed on gastric cells. On primary and metastatic colorectal cancers, GPA33 is overexpressed in 95% of primary and colorectal cancers [1].
Usage and Biology
The single chain fragment targeting GPA33 was used to be fused to the other components of the bispecific antibody to target CD3 and GPA33.
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Categories
Parameters
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