Coding

Part:BBa_K3117020

Designed by: Lena Schorr   Group: iGEM19_FAU_Erlangen   (2019-10-13)
Revision as of 23:01, 21 October 2019 by DSchreyer (Talk | contribs)


scFv VH against CD3 codon optimized for CHO expression

Part BBa_K3117020 is a single chain variable fragment (scFv) of the anti-CD3 antibody. This fragment was used to generate a fusion protein to create a bispecific antibody on the one hand driected against CD3, on the other part against GPA33.



Usage and Biology

CD3 is co-expressed with the T cell receptor on T cells. Binding leads to downstream signaling cascades and activation of the T cell[1].

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