Coding

Part:BBa_K3096017

Designed by: Lina Widerspick, Famke Baeuerle, Patrick Mueller, Jakob Keck   Group: iGEM19_Tuebingen   (2019-10-14)
Revision as of 07:19, 17 October 2019 by Lina widerspick (Talk | contribs)

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SynB1 - cell penetrating peptide

SynB1 is a cell-penetrating peptide that can be fused to a cargo protein to allow it to enter cells. Moreover, SynB1 has been shown to facilitate the delivery of cargo molecule across the blood-brain barrier. The SynB1 peptide is derived from the protein Protegrin, an antimicrobial peptide.

Sequence and Features


Assembly Compatibility:
  • 10
    COMPATIBLE WITH RFC[10]
  • 12
    COMPATIBLE WITH RFC[12]
  • 21
    COMPATIBLE WITH RFC[21]
  • 23
    COMPATIBLE WITH RFC[23]
  • 25
    INCOMPATIBLE WITH RFC[25]
    Illegal AgeI site found at 46
  • 1000
    COMPATIBLE WITH RFC[1000]

Biosafety

Together with professional safety officials, Team iGEM Tuebingen 2019 has evaluated the biosafety of cell penetrating peptides and has come to the conclusion that cell penetrating peptides are to be classified as BSL1.

References

  1. Teuta Opačak-Bernardi and Jung Su Ryu and Drazen Raucher. Effects of cell penetrating Notch inhibitory peptide conjugated to elastin-like polypeptide on glioblastoma cells. Journal of Drug Targeting. Volume 25. Number 6. pages 523-531. 2017. Taylor & Francis.10.1080/1061186X.2017.1289537


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Categories
Parameters
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