Part:BBa_K3282000

This part contains coding sequence of Escherichia coli’s K12 (substr. MG1655) arsenical resistance operon repressor (arsR, Gene ID: 948013, Uniprot: P37309) codon-optimized for Escherichia coli Nissle 1917. The arsR gene which encodes for regulatory proteins, is a part of the ars operon of the E. coli conjugal plasmid R773 (1). ArsR is a 117 residue protein, that has been shown to be a trans‐acting repressor and is a sensor of environmental As(III). This 13 kDa protein belongs to the ArsR family of metalloregulatory proteins that respond to a variety of metals including As(III), Sb(III), Cd(II), and Zn(II) (2).