Coding

Part:BBa_K3102009

Designed by: Chloe DOIZELET   Group: iGEM19_Ionis_Paris   (2019-10-03)
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GND (6-phosphogluconate dehydrogenase)

GND (6-phosphogluconate dehydrogenase) from Corynebacterium glutamicum catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO2, with concomitant reduction of NADP to NADPH in the pentose phosphate pathway. This enzyme catalyzes the following reactions after ZWF and PGL genes. This part is useful to increase flavin production.

"Conformational changes associated with cofactor/substrate binding of 6-phosphogluconate dehydrogenase from Escherichia coli and Klebsiella pneumoniae: Implications for enzyme mechanism." Chen Y.Y., Ko T.P., Chen W.H., Lo L.P., Lin C.H., Wang A.H. J. Struct. Biol. 169:25-35(2010)


Sequence and Features


Assembly Compatibility:
  • 10
    COMPATIBLE WITH RFC[10]
  • 12
    COMPATIBLE WITH RFC[12]
  • 21
    COMPATIBLE WITH RFC[21]
  • 23
    COMPATIBLE WITH RFC[23]
  • 25
    INCOMPATIBLE WITH RFC[25]
    Illegal AgeI site found at 454
  • 1000
    INCOMPATIBLE WITH RFC[1000]
    Illegal SapI.rc site found at 184


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Categories
Parameters
None