Coding

Part:BBa_K3064010

Designed by: Xinyu Su   Group: iGEM19_NUDT_CHINA   (2019-09-25)
Revision as of 15:59, 28 September 2019 by Sxy (Talk | contribs) (→‎Usage and Biology)


mmuTrim21

It is a known type of E3 ubiquitin-protein ligase as an intracellular antibody effector in the antibody-mediated proteolysis pathway.

Usage and Biology

Trim 21 has a particular domain to recognize the Fc domain and combine with antibody marked no-enveloped virions. Using its E3 ubiquitin-protein ligase activity, trim 21 with the antibody bond to virons is degraded by the Ubiquitin dependent protease degradation pathway.

Due to the organism, therapeutic antibodies targeting disease-associated antigens in extracellular is a key tool for some certain diseases in current researches. Although some diseases is not caused by virons, trim 21 can be used in these diseased by blocking a particular pathogenic process.

HA-tag--mmuTrim21.png

Trim21.png

Sequence and Features


Assembly Compatibility:
  • 10
    COMPATIBLE WITH RFC[10]
  • 12
    COMPATIBLE WITH RFC[12]
  • 21
    INCOMPATIBLE WITH RFC[21]
    Illegal BamHI site found at 75
    Illegal BamHI site found at 778
  • 23
    COMPATIBLE WITH RFC[23]
  • 25
    INCOMPATIBLE WITH RFC[25]
    Illegal NgoMIV site found at 176
  • 1000
    COMPATIBLE WITH RFC[1000]


[edit]
Categories
Parameters
None