Part:BBa_K3064021
mmuGlucagon
mmuGlucagon is a hormone secreted by islet alpha cells in the pancreas of mice with insulin.It is a linear polypeptide composed of amino acids.It works against insulin to increase blood sugar content.Glucagon has a strong role in promoting glycogenolysis and gluconeogenesis, which significantly increases blood glucose. Glucagon activates phosphorylase in liver cells through the cAmp-pk system, which accelerates glycogenolysis. Glucagon can also activate lipase, promote the decomposition of fat, and enhance the oxidation of fatty acids, so that ketone body production increased. mmuGlucagon can raise the mice' s glucose content, which creates the condition where we conduct the later experiment related to glucose balance.
Usage and Biology
The hormone is used to raise the glucose content in mice's body so as to create a high-glucose environment. Some of the subsequent experiments are based on the condition.To test our approach's influence on the glucose balance, we need to first increase glucose content so that the changes are easier to discover. Meanwhile, we need to observe changes in hepatic cell metabolism led caused by the change of glucose content, which is affected by Glucagon. On the other hand, as a basic part, it can make up a composite part to act as a navigator which helps the part to bind with GCGR specifically and thus set up the degradation of GCGR. Sequence and Features
- 10COMPATIBLE WITH RFC[10]
- 12COMPATIBLE WITH RFC[12]
- 21COMPATIBLE WITH RFC[21]
- 23COMPATIBLE WITH RFC[23]
- 25COMPATIBLE WITH RFC[25]
- 1000COMPATIBLE WITH RFC[1000]
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