Protein_Domain

Part:BBa_K3064000

Designed by: Zhu Lingyun   Group: iGEM19_NUDT_CHINA   (2019-09-23)
Revision as of 02:53, 27 September 2019 by Elisanda (Talk | contribs) (→‎Usage and Biology)


CHoRE

It is a binding site of CHREBP.

Usage and Biology

Some glycolytic and lipogenic genes respond primarily to glucose, not to insulin. This led to the identification of a consensus sequence that is required for glucose-responsiveness, termed the carbohydrate response element (ChoRE), comprising of two E-boxes (CACGTG) or E-box-like sequences separated by 5 bp [3-5].

Carbohydrate response element binding protein (ChREBP) is an important transcription that can regulate the expression of key genes involved in various pathways including glycolysis, gluconeogenesis and lipogenesis. It does this by forming a tetrameric complex made up of two ChREBP/Mlx heterodimers, which enables it to bind to the carbohydrate response element (ChoRE) in the promoter region. ChoRE should be widely applicable to studying the influence of glucose consentration to cells .


Sequence and Features


Assembly Compatibility:
  • 10
    COMPATIBLE WITH RFC[10]
  • 12
    COMPATIBLE WITH RFC[12]
  • 21
    COMPATIBLE WITH RFC[21]
  • 23
    COMPATIBLE WITH RFC[23]
  • 25
    COMPATIBLE WITH RFC[25]
  • 1000
    COMPATIBLE WITH RFC[1000]


[edit]
Categories
Parameters
None