Coding

Part:BBa_K3064009

Designed by: Jie Cai   Group: iGEM19_NUDT_CHINA   (2019-09-26)
Revision as of 00:57, 27 September 2019 by Registry (Talk | contribs)

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mmuIgG-Fc

Immunoglobulin G (IgG) is a type of antibody，which binds many kinds of pathogens and protects the body from infection. IgG shapes like a Y due to its tetrameric quaternary structure, with two identical class γ heavy chains and two identical light chains. On the bottom of the heavy chain is the fragment crystallizable region (Fc).Fc mediates different physiological effects of antibodies by interacting with various cell receptors and complement proteins. Also, it can be recognized and bound with TRIM21, an E3 ubiquitin-protein ligase that has been applied to a protein degradation method known as Trim-Away.

Sequence and Features


Assembly Compatibility:
  • 10
    COMPATIBLE WITH RFC[10]
  • 12
    COMPATIBLE WITH RFC[12]
  • 21
    COMPATIBLE WITH RFC[21]
  • 23
    COMPATIBLE WITH RFC[23]
  • 25
    COMPATIBLE WITH RFC[25]
  • 1000
    INCOMPATIBLE WITH RFC[1000]
    Illegal BsaI.rc site found at 7


[edit]
Categories
//collections/immune_regulation/antibodies
Parameters
None