Part:BBa_K3128031

Outer Membrane Protein X (OmpX) WT gene

The integral outer membrane protein X (OmpX) from Escherichia coli belongs to a family of highly conserved bacterial proteins. Its role is to promote bacterial adhesion and entry into mammalian cells. These proteins have a role in the resistance against attack by the human complement system.(1)

Structure

OmpX consists of an eight-stranded antiparallel all-next-neighbor beta barrel. The structure shows two girdles of aromatic amino acid residues and a ribbon of nonpolar residues that attach to the membrane interior. The core of the barrel consists of an extended hydrogen-bonding network of highly conserved residues. OmpX thus resembles an inverse micelle. (1)

Figure 1

References

⁽¹⁾ Vogt, J., Schulz G. The structure of the outer membrane protein OmpX from Escherichia coli reveals possible mechanisms of virulence. 1999

Sequence and Features

Assembly Compatibility:

• 10
  COMPATIBLE WITH RFC[10]
• 12
  COMPATIBLE WITH RFC[12]
• 21
  COMPATIBLE WITH RFC[21]
• 23
  COMPATIBLE WITH RFC[23]
• 25
  COMPATIBLE WITH RFC[25]
• 1000
  COMPATIBLE WITH RFC[1000]