Coding

Part:BBa_K2933025

Designed by: Wenhui Gong   Group: iGEM19_TJUSLS_China   (2019-09-05)
Revision as of 03:04, 6 September 2019 by Registry (Talk | contribs)

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subclass B1 beta-lactamase II [Erythrobacter litoralis HTCC2594], codon optimized in E. coli

NDM-23 is a type of subclass B metal beta-lactamases, which is derived from NDM-1 mutation. The beta lactamases of the NDM family can hydrolyze almost all available beta lactam antibiotics (except aztreonam) clinically, including the broad-spectrum antibiotic carbapenems. Because of the extensive substrate profile of this enzyme, the clinical strains carrying it become a great threat to human life and health.

Sequence and Features


Assembly Compatibility:
  • 10
    COMPATIBLE WITH RFC[10]
  • 12
    COMPATIBLE WITH RFC[12]
  • 21
    COMPATIBLE WITH RFC[21]
  • 23
    COMPATIBLE WITH RFC[23]
  • 25
    INCOMPATIBLE WITH RFC[25]
    Illegal AgeI site found at 484
  • 1000
    COMPATIBLE WITH RFC[1000]


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Categories
Parameters
None