Coding

Part:BBa_K2976007

Designed by: Jiatong Chen   Group: iGEM19_CPU_CHINA   (2019-08-04)
Revision as of 02:11, 5 September 2019 by NF-kB pathway (Talk | contribs)


Lamp 2

Usage and Biology

Lysosomal associated membrane protein 2 (Lamp 2) is a member of a family of membrane glycoproteins, which is highly expressed on the surface of exosomes. Much research has indicated that peptides fused to the N terminus of Lamp2 could be effectively displayed on the outer surface of exosomes. In 2019 CPU_CHINA project, we display PD-L1 targeting peptide on outer surface of exosomes and adopt this targeting exosome system to deliver hsa-let-7f into Mtb-infected macrophages specifically.

Sequence and Features


Assembly Compatibility:
  • 10
    COMPATIBLE WITH RFC[10]
  • 12
    COMPATIBLE WITH RFC[12]
  • 21
    COMPATIBLE WITH RFC[21]
  • 23
    COMPATIBLE WITH RFC[23]
  • 25
    COMPATIBLE WITH RFC[25]
  • 1000
    COMPATIBLE WITH RFC[1000]


[edit]
Categories
Parameters
None