Coding
GasderminD

Part:BBa_K2632004

Designed by: Zhujun Xia   Group: iGEM18_HZAU-China   (2018-09-15)
Revision as of 00:28, 18 October 2018 by FengQC (Talk | contribs)

Full length Gasdermin D

Pyroptosis is a form of lytic programmed cell death with inflammation. Recent studies reported that N-terminal of Gasdermin D (BBa K2632003) acts as an effector of pyroptosis. Full length Gasdermin D is cleaved by Caspase 1 and then release the PFD (pore-forming domain) which can oligomerize on the cell membrane. Formation of pores causes cell to swell, leading to rupture of the membrane and massive leakage of cytosolic contents.

Reference

https://www.ncbi.nlm.nih.gov/nuccore/NC_016810

Sequence and Features


Assembly Compatibility:
  • 10
    COMPATIBLE WITH RFC[10]
  • 12
    COMPATIBLE WITH RFC[12]
  • 21
    INCOMPATIBLE WITH RFC[21]
    Illegal XhoI site found at 1204
  • 23
    COMPATIBLE WITH RFC[23]
  • 25
    COMPATIBLE WITH RFC[25]
  • 1000
    INCOMPATIBLE WITH RFC[1000]
    Illegal BsaI.rc site found at 883


[edit]
Categories
Parameters
None