Part:BBa_K2638100

alkyl hydroperoxide reductase, C22 subunit (ahpC)

AhpC scavenges hydrogen peroxide and organic hydroperoxides. Together with AhpF (<a href="https://parts.igem.org/Part:BBa_K2638101">BBa_K2638101</a>) it forms the holoenzyme Ahp / AhpR which catalyzes the reduction of peroxides to alcohols and water respectively. Oxidized AhpC can be restored after reduction by AhpF. Therefore, it offers an alternative to catalases like KatE and KatG. However AhpC is saturated at relatively low concentrations (10^(-5) M). If Ahp works properly and no highly oxidative stress is present, Ahp is sufficient to keep hydrogen peroxide concentrations low enough to prevent the activation of the OxyR regulon. AhpC catalyzes the following reaction: 2 R'-SH + ROOH = R'-S-S-R' + H(2)O + ROH.

Sequence and Features

Assembly Compatibility:

• 10
  COMPATIBLE WITH RFC[10]
• 12
  COMPATIBLE WITH RFC[12]
• 21
  COMPATIBLE WITH RFC[21]
• 23
  COMPATIBLE WITH RFC[23]
• 25
  COMPATIBLE WITH RFC[25]
• 1000
  COMPATIBLE WITH RFC[1000]