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Regulatory
Part:BBa_K2865000:Design
Designed by: Group: iGEM18_SMMU-China (2018-09-22)
BNP promoter, heart failure inducible
Assembly Compatibility:
- 10COMPATIBLE WITH RFC[10]
- 12COMPATIBLE WITH RFC[12]
- 21COMPATIBLE WITH RFC[21]
- 23COMPATIBLE WITH RFC[23]
- 25COMPATIBLE WITH RFC[25]
- 1000INCOMPATIBLE WITH RFC[1000]Illegal BsaI site found at 242
Design Notes
We selected this range of sequence for it contains several regulatory elements and could be activated by a few factors, including endothelin (ET), angiotensin II (Ang II), and hypoxia.
Source
This promoter is synthesized from Homo sapiens natriuretic peptide precursor B (NPPB) gene.