Part:BBa_K2440031
miR-155 target sequence
It is the target sequence of miR-155, a modularized DNA part from a set of chemically synthetic oligo DNA library.
Usage and Biology
MiRNA locker assembled by using this modularized DNA part was able to bind miR-155 in an Ago2 dependent manner, that is, knockdown of miR-155 was achieved by transfecting cells with miRNA locker.
Dre-miR155 was firstly found in zebrafish.1
MiR-155-5p are highly expressed in the heart and regulate cardiac development. What’s more, miR-155-5p was overexpressed in trisomic hearts.2
MiR-155 downregulation in NK cells of IA patients impaired IFN-γ production by targeting SOCS1, which may contribute to immune dysfunction during CHB infection. Additionally, baseline miR-155 expression could predict the treatment response to telbivudine therapy.3
Sequence and Features
Sequence and Features
- 10COMPATIBLE WITH RFC[10]
- 12COMPATIBLE WITH RFC[12]
- 21COMPATIBLE WITH RFC[21]
- 23COMPATIBLE WITH RFC[23]
- 25COMPATIBLE WITH RFC[25]
- 1000COMPATIBLE WITH RFC[1000]
Experimental Validation
This part is sequenced as correct after construction.
None |