Protein_Domain

Part:BBa_K2520038

Designed by: Noa Eden   Group: iGEM17_TECHNION-ISRAEL   (2017-10-25)
Revision as of 09:27, 27 October 2017 by Noa eden (Talk | contribs)


MOG1

Introduction

In MS, the immune system attacks the protective sheath (myelin) that covers nerve fibers and causes communication problems between your brain and the rest of your body. Eventually, the disease can cause the nerves themselves to deteriorate or become permanently damaged.

In MS disease, T cells attack 3 types of glycoprotein: 1) Myelin basic protein (MBP) 2) Proteolipid protein (PLP) 3) myelin oligodendrocyte glycoprotein (MOG)

Experimental autoimmune encephalomyelitis (EAE)

EAE is a CD4' T cell-mediated inflammatory disease of the central nervous system (CNS) induced in experimental animals with CNS homogenate, myelin or myelin components. In its chronic form, EAE is a well accepted experimental model for multiple sclerosis (MS).

Epitopes

Sequence and Features


Assembly Compatibility:
  • 10
    COMPATIBLE WITH RFC[10]
  • 12
    COMPATIBLE WITH RFC[12]
  • 21
    COMPATIBLE WITH RFC[21]
  • 23
    COMPATIBLE WITH RFC[23]
  • 25
    COMPATIBLE WITH RFC[25]
  • 1000
    COMPATIBLE WITH RFC[1000]


[edit]
Categories
Parameters
None