Part:BBa_K2368004
Introduction
T1R2
The protein encoded by the T1R2 gene is a G protein-coupled receptor with seven trans-membrane domains and is a component of the heterodimeric amino acid taste receptor T1R1+3 and sweet taste receptor T1R2+3. This receptor is formed as a protein dimer with either T1R1 or T1R2. Experiments have also shown that a homo-dimer of T1R2 is also sensitive to natural sugar substances. This has been hypothesized as the mechanism by which sugar substitutes do not have the same taste qualities as natural sugars.
Originally, T1R1+3 expressing cells are found in fungiform papillae at the tip and edges of the tongue and palate taste receptor cells in the roof of the mouth. These cells are shown to synapse upon the chorda tympani nerves to send their signals to the brain. T1R2+3 expressing cells are found in circumvallate papillae and foliate papillae near the back of the tongue and palate taste receptor cells in the roof of the mouth. These cells are shown to synapse upon the glossopharyngeal nerves to send their signals to the brain.
File:T-BIT-China-2017parts-11.png
Fig. 1 The schematic diagram of T1R2/T1R3 in cytomembrane</i>
Sequence and Features
- 10COMPATIBLE WITH RFC[10]
- 12COMPATIBLE WITH RFC[12]
- 21INCOMPATIBLE WITH RFC[21]Illegal BglII site found at 1369
Illegal BglII site found at 1789
Illegal BglII site found at 1951
Illegal XhoI site found at 396 - 23COMPATIBLE WITH RFC[23]
- 25INCOMPATIBLE WITH RFC[25]Illegal AgeI site found at 880
Illegal AgeI site found at 2098 - 1000COMPATIBLE WITH RFC[1000]
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