Coding

Part:BBa_K1954000

Designed by: Kamil Zmijewski   Group: iGEM16_UCL   (2016-09-12)
Revision as of 13:01, 12 September 2016 by Zcbtkjz (Talk | contribs)


LanA This entry is the open reading frame for the mutacin 1140 prepropeptide from Streptococcus mutans JH1140. Mutacin 1140 is type A lantibiotic (a linear antimicrobial peptide) differing from other bacteriocins by the presence of distinct post-translational modifications. The mature mutacin peptide is a screw-shaped molecule that interferes with the longevity of Gram-positive bacteria by means of membrane perturbation. In order for mutacin 1140 to be functional the action of modifying enzymes is required. These enzymes catalyze the formation of stereospecific thioether bridges, dehydration, decarboxylation of the core peptide and leader peptide cleavage, as well as act as exporters of the modified mutacin.


Sequence and Features


Assembly Compatibility:
  • 10
    COMPATIBLE WITH RFC[10]
  • 12
    COMPATIBLE WITH RFC[12]
  • 21
    INCOMPATIBLE WITH RFC[21]
    Illegal BglII site found at 57
  • 23
    COMPATIBLE WITH RFC[23]
  • 25
    COMPATIBLE WITH RFC[25]
  • 1000
    COMPATIBLE WITH RFC[1000]


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Categories
Parameters
None