Plasmid

Part:BBa_K1391007:Experience

Designed by: Alexa Garcia   Group: iGEM14_MIT   (2014-10-16)
Revision as of 22:56, 1 November 2014 by Krbrink (Talk | contribs)

This experience page is provided so that any user may enter their experience using this part.
Please enter how you used this part and how it worked out.

Applications of BBa_K1391007

This is fusion protein comprising Syk and tobacco etch virus (TEV) protease, joined by a glycine-serine linker.

B-cell receptors (BCRs) are naturally occurring, transmembrane protein complexes that consist of a membrane-bound antibody (IgM) and some associated proteins (CD79A and CD79B). Given that the variable region of the antibody can be specific for any of a large number of antigens, we designed a B-cell receptor to bind beta-amyloid plaques (a biomolecular hallmark of Alzheimer's disease). Once bound, activated receptors instigate intracellular signalling, which can then be manipulated to diagnose the disease.

User Reviews

UNIQf1a4c86f9edb4e30-partinfo-00000000-QINU UNIQf1a4c86f9edb4e30-partinfo-00000001-QINU