Plasmid
Part:BBa_K1391102:Experience
Designed by: Shinjini Saha Group: iGEM14_MIT (2014-10-17)
Revision as of 20:16, 1 November 2014 by Clrichar (Talk | contribs) (→Applications of BBa_K1391102)
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Applications of BBa_K1391102
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B-cell receptors (BCRs) are naturally occurring, transmembrane protein complexes that consist of a membrane-bound antibody (IgM) and some associated proteins (CD79A and CD79B). Given that the variable region of the antibody can be specific for any of a large number of antigens, we designed a B-cell receptor to bind beta-amyloid plaques (a biomolecular hallmark of Alzheimer's disease). Once bound, activated receptors instigate intracellular signalling, which can then be manipulated to diagnose the disease. |