Part:BBa_K1458004

Human AdipoQ gene

The AdipoQ gene which codes for the protein adiponectin has domains similar to collagens X and VIII and complement factor C1q. Adiponectin forms multimeric complexes that combine via its collagen domains to create three major oligomeric forms: a low molecular weight (LMW) trimer, a middle - molecular weight (MMW) hexamer, and high molecular weight (HMW) 12-18- mer Adiponectin. Normally it is expressed exclusively in adipose tissues from which it is secreted to the blood stream. It directly sensitizes the body to insulin and has an important role in lipid and glucose metabolism regulation. Therefore adiponectin represents a potential therapeutic target to fighting obesity-linked diseases characterized by insulin resistance and the Metabolic Syndrom. Furthermore low levels of serum Adiponectin is highly related with occurrence of abdominal obesity, insulin resistance, type 2 diabetes, and the metabolic syndrome.

Kadowaki, T., Yamauchi, T., Kubota, N., Hara, K., Ueki, K., & Tobe, K. (2006). Review series Adiponectin and adiponectin receptors in insulin resistance , diabetes , and the metabolic syndrome. J Clin Invest., 116(7), 1784–1792.

Sequence and Features

Assembly Compatibility:

• 10
  COMPATIBLE WITH RFC[10]
• 12
  COMPATIBLE WITH RFC[12]
• 21
  INCOMPATIBLE WITH RFC[21]

  Illegal BglII site found at 401
  
• 23
  COMPATIBLE WITH RFC[23]
• 25
  COMPATIBLE WITH RFC[25]
• 1000
  INCOMPATIBLE WITH RFC[1000]

  Illegal SapI site found at 546