Plasmid

Part:BBa_K1391008

Designed by: Alexa Garcia   Group: iGEM14_MIT   (2014-10-16)
Revision as of 00:45, 17 October 2014 by Registry (Talk | contribs)

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Lyn

Lyn is a Tyrosine-protein kinase responsible for phosphorylating the immunoreceptor tyrosine-based activation motif (ITAM) of a B-Cell Receptor (BCR) Complex upon antigen binding. When the BCR binds it's specific antigen the receptor dimerizes and recruits Lyn which phosphorylates the ITAMs of the CD79A and CD79B proteins in the BCR Complex. This allows the receptor to phosphorylate Syk and initiate a downstream signalling cascade.


Sequence and Features


Assembly Compatibility:
  • 10
    INCOMPATIBLE WITH RFC[10]
    Illegal PstI site found at 889
  • 12
    INCOMPATIBLE WITH RFC[12]
    Illegal PstI site found at 889
  • 21
    COMPATIBLE WITH RFC[21]
  • 23
    INCOMPATIBLE WITH RFC[23]
    Illegal PstI site found at 889
  • 25
    INCOMPATIBLE WITH RFC[25]
    Illegal PstI site found at 889
  • 1000
    INCOMPATIBLE WITH RFC[1000]
    Illegal BsaI site found at 1122
    Illegal BsaI.rc site found at 1458
    Illegal SapI.rc site found at 993


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Categories
Parameters
None