Coding

Part:BBa_K1458005

Designed by: Shani Gal-Oz   Group: iGEM14_BGU_Israel   (2014-10-15)
Revision as of 13:00, 15 October 2014 by Registry (Talk | contribs)

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Human DsbA-L (GSTK1) gene

DsbA-L is a protein present in the ER (endoplasmic reticulum). Its main action is a Glutathione S-Transferase action on the hormone adiponectin. It has the ability to catalyze the conjugation of the reduced form of glutathione (GSH) to xenobiotic substrates for the purpose of detoxification, and it helps with binding two substrates with to s-s bonds and cellular detoxification. DsbA-L is expressed mostly in adipose tissue, and its expression level is negatively correlated with the obesity of mice and humans.

DsbA-L has been shown to bind adiponectin and increase the production of the HMW species, for that it can become a novel therapeutic and industrial target.


Sequence and Features


Assembly Compatibility:
  • 10
    COMPATIBLE WITH RFC[10]
  • 12
    COMPATIBLE WITH RFC[12]
  • 21
    COMPATIBLE WITH RFC[21]
  • 23
    COMPATIBLE WITH RFC[23]
  • 25
    COMPATIBLE WITH RFC[25]
  • 1000
    INCOMPATIBLE WITH RFC[1000]
    Illegal BsaI.rc site found at 508
    Illegal SapI site found at 27


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Categories
Parameters
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