Part:BBa_K1019004

YdeH Diguanylate Cyclase

YdeH is a dyguanylate cyclase that is involved in producing the key secondary messenger c-di-GMP. c-di-GMP is propoed to be a "master regulator" of biofilm formation.

Its expression increases surface adhesion and various aspects of the biofilm response.

For further details and additional references please visit [http://ecocyc.org/ECOLI/NEW-IMAGE?type=GENE&object=EG11643 EcoCyc]

References

Jonas, K., Edwards, A. N., Simm, R., Romeo, T., Römling, U., & Melefors, Ö. (2008). The RNA binding protein CsrA controls cyclic di‐GMP metabolism by directly regulating the expression of GGDEF proteins. Molecular microbiology, 70(1), 236-257.

Boehm, A., Steiner, S., Zaehringer, F., Casanova, A., Hamburger, F., Ritz, D., ... & Jenal, U. (2009). Second messenger signalling governs Escherichia coli biofilm induction upon ribosomal stress. Molecular microbiology, 72(6), 1500-1516.

Steiner, S., Lori, C., Boehm, A., & Jenal, U. (2012). Allosteric activation of exopolysaccharide synthesis through cyclic di-GMP-stimulated protein–protein interaction. The EMBO journal.

Sequence and Features

Assembly Compatibility:

• 10
  COMPATIBLE WITH RFC[10]
• 12
  COMPATIBLE WITH RFC[12]
• 21
  COMPATIBLE WITH RFC[21]
• 23
  COMPATIBLE WITH RFC[23]
• 25
  COMPATIBLE WITH RFC[25]
• 1000
  INCOMPATIBLE WITH RFC[1000]

  Illegal SapI.rc site found at 775
  Illegal SapI.rc site found at 800