![](https://parts.igem.org/images/partbypart/icon_coding.png)
Coding
MarA
Part:BBa_K1230000
Designed by: Andrés Ferriño Iriarte Group: iGEM13_Ciencias-UNAM (2013-09-08)
AcrAB-TolC multidrug efflux transport system activator from E. coli
The MarA protein acts as a transcriptional activator in E. coli, it allows the expression of the acrAB and tolC operons, which activate the AcrAB-TolC efflux pump, a mechanism that has been related with resistance to organic solvents, dyes, detergents, antibiotics such as chloramphenicol, tetracycline, novobiocin, erythromycin, fusidic acid and cloxacillin, as well as to cationic antimicrobial peptides, such as LL-37, HNP-2 and HBD-1.
Sequence and Features
Assembly Compatibility:
- 10COMPATIBLE WITH RFC[10]
- 12COMPATIBLE WITH RFC[12]
- 21COMPATIBLE WITH RFC[21]
- 23COMPATIBLE WITH RFC[23]
- 25INCOMPATIBLE WITH RFC[25]Illegal AgeI site found at 154
- 1000COMPATIBLE WITH RFC[1000]
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Categories
Parameters
//regulation/positive
n/a | AcrAB-TolC multidrug efflux transport system activator from E. coli |