Part:BBa_K861400

For a E.coli to degrade fatty acid, at least four enzymes – FadA, FadB, FadD, FadE 

and transporter—FadL are needed. Long chain fatty acids(FAs) are firstly being imported

by the transmembrane protein FadL. After FAs get into cells, they will be added a CoA
by inner membrane-associated FadD (acyl-CoA synthase). β-oxidation is initiated by
FadE(acyl-CoA dehydrogenase), which will convert acyl-CoA into enoyl-CoA. The followed cycles
of hydration, oxidation, and thiolytic cleavage are carried out by tetrameric complex consisting
of two FadA and two FadB proteins.