Coding
memory hel

Part:BBa_K896969:Design

Designed by: En-Jie Shih   Group: iGEM12_NYMU-Taipei   (2012-04-26)
Revision as of 11:57, 27 April 2012 by Mso472197 (Talk | contribs) (→‎Design Notes)

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testican-1


Assembly Compatibility:
  • 10
    COMPATIBLE WITH RFC[10]
  • 12
    INCOMPATIBLE WITH RFC[12]
    Illegal NotI site found at 26
  • 21
    COMPATIBLE WITH RFC[21]
  • 23
    COMPATIBLE WITH RFC[23]
  • 25
    INCOMPATIBLE WITH RFC[25]
    Illegal NgoMIV site found at 4
    Illegal NgoMIV site found at 63
  • 1000
    INCOMPATIBLE WITH RFC[1000]
    Illegal BsaI site found at 929
    Illegal SapI site found at 647


Design Notes

Several functions of this gene product have now been demonstrated in vitro including membrane-type matrix metalloproteinase inhibition, cathepsin L inhibition, and low-affinity calcium binding. The purified gene product has been shown to inhibit cell attachment and neurite extensions in culture. Functions of testican in vivo have yet to be demonstrated in knockout mice or other models. Testican has been shown to carry substantial amounts of chondroitin sulfate as well as other oligosaccharides, but the biological significance of these embellishments is not yet known.

Source

Macaca mulatta (Rhesus monkey)protein domains


* [http://www.ncbi.nlm.nih.gov/pubmed/15261737]

References

  • Edgell CJ, BaSalamah MA, Marr HS,Pathology Department, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599-7525, USA, Int Rev Cytol. 2004;236:101-22.
  • Yen-Yu Lai,成功大學生理學研究所,In searching of new candidate genes for memory formation—characterization of testican genes in the rat brain,2003