Coding

Part:BBa_K364307

Designed by: Lior Malka   Group: iGEM10_Debrecen-Hungary   (2010-09-28)
Revision as of 20:22, 25 October 2010 by Daniel87 (Talk | contribs)

Human ER DBD

Estrogen receptor refers to a group of receptors that are activated by the hormone 17β-estradiol[1] (estrogen) , which is a member of the nuclear hormone family of intracellular receptors. The main function of the estrogen receptor is as a DNA-binding transcription factor that regulates gene expression.

More on ER here: [http://en.wikipedia.org/wiki/RXRA].

ER Uniprot: [http://www.uniprot.org/uniprot/P03372].

View the ER DBD crystal structure here: [http://www.pdb.org/pdb/explore/jmol.do?structureId=1HCQ&bionumber=1].

Picture of human ER DNA binding domain.

Description of the RXRa DBD crystal structure with reference here: [http://www.cell.com/retrieve/pii/009286749390390C].


Sequence and Features


Assembly Compatibility:
  • 10
    COMPATIBLE WITH RFC[10]
  • 12
    COMPATIBLE WITH RFC[12]
  • 21
    COMPATIBLE WITH RFC[21]
  • 23
    COMPATIBLE WITH RFC[23]
  • 25
    COMPATIBLE WITH RFC[25]
  • 1000
    COMPATIBLE WITH RFC[1000]


[edit]
Categories
Parameters
None