Coding

Part:BBa_K364310:Experience

Designed by: Lior Malka   Group: iGEM10_Debrecen-Hungary   (2010-09-29)
Revision as of 23:11, 24 October 2010 by Lityupix (Talk | contribs) (→‎Applications of BBa_K364310)

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Physiological effects of EcR

Pulses of 20-hydroxyecdysone occur during insect development, whereupon this hormone binds to the ecdysone receptor, a ligand-activated transcription factor found in the nuclei of insect cells.[1] This in turn leads to the activation of many other genes, as evidenced by chromosomal puffing at over a hundred sites. Ultimately the activation cascade causes physiological changes that result in ecdysis (moulting).

Potential applications of EcR LBD

EcR LBD can be fused with different DBDs in order to activate downstream gene expression depending on the binding site of the DBD.

User Reviews

UNIQe39f6af03da0b8f6-partinfo-00000000-QINU UNIQe39f6af03da0b8f6-partinfo-00000001-QINU