Protein_Domain
Part:BBa_K5310010:Design
Designed by: Ilias Pilianidis Group: iGEM24_thessaloniki (2024-09-30)
CD137 signalling domain
Assembly Compatibility:
- 10COMPATIBLE WITH RFC[10]
- 12COMPATIBLE WITH RFC[12]
- 21COMPATIBLE WITH RFC[21]
- 23COMPATIBLE WITH RFC[23]
- 25COMPATIBLE WITH RFC[25]
- 1000COMPATIBLE WITH RFC[1000]
Design Notes
The sequence was retrieved from the NCBI database, the domain's use was evaluated in the literature, and the sequence was codon optimized for expression in human primary cell lines.
Source
The 4-1-BB signalling domain sequence was retrieved from the CD28 gene that resides on chromosome 2 of the human genome.