Coding

Part:BBa_K5477019

Designed by: Kate Escobar, Victor Bay and Christian Gejl Christensen   Group: iGEM24_UCopenhagen   (2024-09-26)
Revision as of 17:24, 26 September 2024 by Registry (Talk | contribs)

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CYP1A1 - Cytochrome P450 1A1 from Rattus norvegicus

CYP1A1 (Cytochrome P450 1A1) is a vital enzyme in the cytochrome P450 family that primarily metabolizes environmental toxins, including polycyclic aromatic hydrocarbons (PAHs), dioxins, and polychlorinated biphenyls (PCBs). Predominantly expressed in the lungs and liver, CYP1A1 plays a key role in phase I metabolism, where it oxidizes hydrophobic compounds, rendering them more polar and easier to excrete. CYP1A1 catalyzes the incorporation of an oxygen atom into its substrates, producing reactive intermediates that are often further processed by phase II enzymes like UGT1A1 through glucuronidation. By metabolizing these carcinogenic and mutagenic compounds, CYP1A1 helps protect the body from toxic environmental exposures.


Sequence and Features


Assembly Compatibility:
  • 10
    INCOMPATIBLE WITH RFC[10]
    Illegal PstI site found at 232
    Illegal PstI site found at 1434
  • 12
    INCOMPATIBLE WITH RFC[12]
    Illegal PstI site found at 232
    Illegal PstI site found at 1434
  • 21
    COMPATIBLE WITH RFC[21]
  • 23
    INCOMPATIBLE WITH RFC[23]
    Illegal PstI site found at 232
    Illegal PstI site found at 1434
  • 25
    INCOMPATIBLE WITH RFC[25]
    Illegal PstI site found at 232
    Illegal PstI site found at 1434
    Illegal NgoMIV site found at 326
    Illegal NgoMIV site found at 413
  • 1000
    COMPATIBLE WITH RFC[1000]


[edit]
Categories
Parameters
None