Coding

Part:BBa_K5374025

Designed by: Yiqi Meng   Group: iGEM24_TestDaily-I-Beijing   (2024-09-24)
Revision as of 11:34, 24 September 2024 by Registry (Talk | contribs)

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FTD-BMP-4 (Fibrinogen-like Domain fused with Bone Morphogenetic Protein-4). A fusion protein combini

The Fibrinogen-like Domain (FTD) provides strong collagen-binding properties, enabling the fusion protein to localize in collagen-rich environments. BMP-4 is a key growth factor involved in the differentiation of mesenchymal stem cells into osteoblasts, thus promoting bone formation and regeneration. By fusing BMP-4 with the FTD, the protein can be directed specifically to collagen-based scaffolds, ensuring a localized and sustained release of BMP-4. This is particularly useful in bone repair applications, where BMP-4 needs to be concentrated at the site of injury to stimulate effective bone regeneration.

Sequence and Features


Assembly Compatibility:
  • 10
    INCOMPATIBLE WITH RFC[10]
    Illegal PstI site found at 163
    Illegal PstI site found at 304
    Illegal PstI site found at 629
    Illegal PstI site found at 1096
    Illegal PstI site found at 1237
    Illegal PstI site found at 1618
    Illegal PstI site found at 1699
  • 12
    INCOMPATIBLE WITH RFC[12]
    Illegal NheI site found at 1495
    Illegal PstI site found at 163
    Illegal PstI site found at 304
    Illegal PstI site found at 629
    Illegal PstI site found at 1096
    Illegal PstI site found at 1237
    Illegal PstI site found at 1618
    Illegal PstI site found at 1699
  • 21
    COMPATIBLE WITH RFC[21]
  • 23
    INCOMPATIBLE WITH RFC[23]
    Illegal PstI site found at 163
    Illegal PstI site found at 304
    Illegal PstI site found at 629
    Illegal PstI site found at 1096
    Illegal PstI site found at 1237
    Illegal PstI site found at 1618
    Illegal PstI site found at 1699
  • 25
    INCOMPATIBLE WITH RFC[25]
    Illegal PstI site found at 163
    Illegal PstI site found at 304
    Illegal PstI site found at 629
    Illegal PstI site found at 1096
    Illegal PstI site found at 1237
    Illegal PstI site found at 1618
    Illegal PstI site found at 1699
  • 1000
    COMPATIBLE WITH RFC[1000]


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Categories
Parameters
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