Coding
Part:BBa_K5374025
Designed by: Yiqi Meng Group: iGEM24_TestDaily-I-Beijing (2024-09-24)
FTD-BMP-4 (Fibrinogen-like Domain fused with Bone Morphogenetic Protein-4). A fusion protein combini
The Fibrinogen-like Domain (FTD) provides strong collagen-binding properties, enabling the fusion protein to localize in collagen-rich environments. BMP-4 is a key growth factor involved in the differentiation of mesenchymal stem cells into osteoblasts, thus promoting bone formation and regeneration. By fusing BMP-4 with the FTD, the protein can be directed specifically to collagen-based scaffolds, ensuring a localized and sustained release of BMP-4. This is particularly useful in bone repair applications, where BMP-4 needs to be concentrated at the site of injury to stimulate effective bone regeneration.
Sequence and Features
Assembly Compatibility:
- 10INCOMPATIBLE WITH RFC[10]Illegal PstI site found at 163
Illegal PstI site found at 304
Illegal PstI site found at 629
Illegal PstI site found at 1096
Illegal PstI site found at 1237
Illegal PstI site found at 1618
Illegal PstI site found at 1699 - 12INCOMPATIBLE WITH RFC[12]Illegal NheI site found at 1495
Illegal PstI site found at 163
Illegal PstI site found at 304
Illegal PstI site found at 629
Illegal PstI site found at 1096
Illegal PstI site found at 1237
Illegal PstI site found at 1618
Illegal PstI site found at 1699 - 21COMPATIBLE WITH RFC[21]
- 23INCOMPATIBLE WITH RFC[23]Illegal PstI site found at 163
Illegal PstI site found at 304
Illegal PstI site found at 629
Illegal PstI site found at 1096
Illegal PstI site found at 1237
Illegal PstI site found at 1618
Illegal PstI site found at 1699 - 25INCOMPATIBLE WITH RFC[25]Illegal PstI site found at 163
Illegal PstI site found at 304
Illegal PstI site found at 629
Illegal PstI site found at 1096
Illegal PstI site found at 1237
Illegal PstI site found at 1618
Illegal PstI site found at 1699 - 1000COMPATIBLE WITH RFC[1000]
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Categories
Parameters
None |