Coding

Part:BBa_K5317017

Designed by: Vanessa Bruhn   Group: iGEM24_Hannover   (2024-09-22)
Revision as of 16:28, 23 September 2024 by Vanessa09 (Talk | contribs) (→‎Usage and Biology)

3xCre3xAP1-miniCMV Promoter

Usage and Biology

ATF2 belongs to the ATF/CREB family and regulates genes involved in cell growth, stress responses and apoptosis. With the addition of the ATF2 gene, this plasmid enables the study of transcriptional regulation of ATF2 (Kirsch et al., 2020) and its phosphorylation by PknB, making it important for research into signaling pathways related to cell stress and survival (Zhang et al., 2020). The consensus sequence for the CRE (cAMP-responsive elements) sequence that ATF2 binds to is typically represented as 5'-GTGACGT[AC][AG]-3' (Hai et al.,1989).

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