Coding

Part:BBa_K5374019

Designed by: Yiqi Meng   Group: iGEM24_TestDaily-I-Beijing   (2024-09-19)
Revision as of 03:23, 19 September 2024 by Registry (Talk | contribs)

(diff) ← Older revision | Latest revision (diff) | Newer revision → (diff)


FTD-BMP-4 (Fibrinogen-like Domain fused with Bone Morphogenetic Protein-4). A fusion protein combini

The Fibrinogen-like Domain (FTD) provides strong collagen-binding properties, enabling the fusion protein to localize in collagen-rich environments. BMP-4 is a key growth factor involved in the differentiation of mesenchymal stem cells into osteoblasts, thus promoting bone formation and regeneration. By fusing BMP-4 with the FTD, the protein can be directed specifically to collagen-based scaffolds, ensuring a localized and sustained release of BMP-4. This is particularly useful in bone repair applications, where BMP-4 needs to be concentrated at the site of injury to stimulate effective bone regeneration.

Sequence and Features


Assembly Compatibility:
  • 10
    COMPATIBLE WITH RFC[10]
  • 12
    COMPATIBLE WITH RFC[12]
  • 21
    COMPATIBLE WITH RFC[21]
  • 23
    COMPATIBLE WITH RFC[23]
  • 25
    COMPATIBLE WITH RFC[25]
  • 1000
    COMPATIBLE WITH RFC[1000]


[edit]
Categories
Parameters
None