Part:BBa_K4990012
Tumor-Targeting Rod
You need to know
Acurate targeting is one important characteristics for many emerging cancer therapies, that is also what ourproject’s ambition. We designed two fusion proteins, they function like fishingrod, so we gave them the name: Fishing Rod Proteins (FRPs). The one that targetFn names Bacteria Tageting Rod(BTR), the other that target CRC cells names Tumor Tageting Rod(TTR). FRPs are displayed on engineered BL membranes, helping BLtarget to the correct place. Of course, their targets are cancer cells and Fn,rather than fish. Each FRP consists of four parts (Figure1): the signal peptide(white),helping FRPs locate on cell membrane; the membrane protein(pink), the base ofFRPs; and the linker(blue), helping FRPs become flexible; and the targeting fragments(yellow), the most pivotal role in FRPs
Sequence and Features
- 10INCOMPATIBLE WITH RFC[10]Illegal PstI site found at 358
- 12INCOMPATIBLE WITH RFC[12]Illegal PstI site found at 358
- 21INCOMPATIBLE WITH RFC[21]Illegal BamHI site found at 771
- 23INCOMPATIBLE WITH RFC[23]Illegal PstI site found at 358
- 25INCOMPATIBLE WITH RFC[25]Illegal PstI site found at 358
Illegal NgoMIV site found at 1050
Illegal NgoMIV site found at 1590 - 1000COMPATIBLE WITH RFC[1000]
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