Part:BBa_K4683005
hsa-miR-20b
The concentration of hsa-miR-20b is positively correlated with that of estrogen (Pérez-Cremades et al., 2018). Like the estrogen molecule, miR-20b activates the ERα pathway, regulating the production of CAD suppressors (Pérez-Cremades et al., 2018), making miR-20b an ideal miRNA to target with our rolling circle amplification (RCA) assay.
hsa-miR-20b is used as the basis for BBa_K4683006 and BBa_K4683007, the 3' arm for hsa-mir-20b and 5' arm for hsa-mir-20b, and as the target sequence for BBa_K4683008.
References
Pérez-Cremades, D., Mompeón, A., Vidal-Gómez, X., Hermenegildo, C., & Novella, S. (2018, February 6). MIRNA as a new regulatory mechanism of Estrogen Vascular Action. International journal of molecular sciences. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5855695/#B24-ijms-19-00473
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