Part:BBa_K4907023

Mn-SOD

Biology

The partial reduction of oxygen leads to the formation of various reactive oxygen species (ROS). Superoxide anion radical (O₂•−) is usually the first ROS to be generated. The efficiency of enzymatic reactions decreases at low temperature, leading to the accumulation of intracellular peroxides and causing damage, which is one of the mechanisms of bacterial cold injury. SODs are the main antioxidant enzyme families in organisms. They are considered as the first defense line against oxidative stresses due to their function of converting O2·− to H2O2 and H2O (1,2). Mn-SOD, a subtype of SOD, utilizes manganese (Mn) as a cofactor, existing in the form of a homotetramer. It is located within the mitochondria of aerobic cells. The expression of Mn-SOD gene in several insect species increased their survival at low temperature (3).

Sequence and Features

Assembly Compatibility:

• 10
  COMPATIBLE WITH RFC[10]
• 12
  COMPATIBLE WITH RFC[12]
• 21
  COMPATIBLE WITH RFC[21]
• 23
  COMPATIBLE WITH RFC[23]
• 25
  COMPATIBLE WITH RFC[25]
• 1000
  COMPATIBLE WITH RFC[1000]