Coding

Part:BBa_K4586009

Designed by: Mohamed Mohamed Saad Aboelghare   Group: iGEM23_AFCM-Egypt   (2023-09-15)
Revision as of 09:43, 20 September 2023 by Ahmed Mattar (Talk | contribs)


lamp2b

Part Description

It is the transmembrane protein known as lysosome-associated membrane glycoprotein 2b, which is unique to the membrane of exosomes. LAMP2B mutation can cause danon disease that manifests with the clinical triad of cardiomyopathy, skeletal myopathy, and intellectual disability

Usage

This part is used to express citrullinated vimentin on the exosomal surface to increase the exosomes' affinity for the autoreactive B-cells, as this transmembrane protein is unique to the membrane of exosomes and lysosomes, so the likelihood of exosome and B-cell fusion has significantly increased. Sequence and Features


Assembly Compatibility:
  • 10
    COMPATIBLE WITH RFC[10]
  • 12
    COMPATIBLE WITH RFC[12]
  • 21
    COMPATIBLE WITH RFC[21]
  • 23
    COMPATIBLE WITH RFC[23]
  • 25
    COMPATIBLE WITH RFC[25]
  • 1000
    COMPATIBLE WITH RFC[1000]


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Categories
Parameters
None