Part:BBa_K4656007
Plam-TPH-TDC
Under the activation of Plam, downstream genes TPH1 and TDC1 are expressed. The Tph1 gene encodes tryptophan hydroxylase (TPH) and the Tdc1 gene encodes tryptophan decarboxylase (TDC). These two enzymes play a huge role in the production of 5-HT. Tryptophan decarboxylase (TDC) is the key enzyme, which can catalyze the conversion of tryptophan (an essential amino acid) to 5-hydroxytryptophan (5-HTP). Tryptophan hydroxylase (TDC) can remove the carboxyl group of 5-hydroxytryptophan (5-HTP) and convert it into serotonin (5-hydroxytryptophan, 5-HT) molecules. Serotonin can play a role in promoting intestinal motility, which is beneficial for improving constipation. Notably, promoter Plam can be inhibited by binding to CI repressor proteins.
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