Coding

Part:BBa_K4656002

Designed by: Xinji Gu   Group: iGEM23_NMU-China   (2023-08-07)
Revision as of 02:29, 8 August 2023 by Registry (Talk | contribs)

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TPH 


  Tph1 is the gene encoding tryptophan hydroxylase (TPH), which plays an important role in the synthesis of serotonin (5-hydroxytryptamine, 5-HT), in which the rate-limiting step is catalyzed by TPH. The Tph1 gene expresses the TPH1 protein, which converts tryptophan (an essential amino acid) to 5-hydroxytryptophan (5-HTP). 

  As a neurotransmitter, serotonin can play the role of intestinal motility. If its secretion is insufficient, it can easily lead to the decline of intestinal motility, and then lead to chronic constipation. Therefore, constructing plasmids introducing Tph1 gene and promoting TPH expression is conducive to the treatment of chronic constipation.

Sequence and Features


Assembly Compatibility:
  • 10
    COMPATIBLE WITH RFC[10]
  • 12
    INCOMPATIBLE WITH RFC[12]
    Illegal NheI site found at 898
  • 21
    COMPATIBLE WITH RFC[21]
  • 23
    COMPATIBLE WITH RFC[23]
  • 25
    INCOMPATIBLE WITH RFC[25]
    Illegal AgeI site found at 673
  • 1000
    INCOMPATIBLE WITH RFC[1000]
    Illegal SapI.rc site found at 240


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Parameters
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