Protein_Domain

Part:BBa_K4175003

Designed by: Li Xianxiu, Zhang Wanying   Group: iGEM22_ZJUintl-China   (2022-08-27)
Revision as of 05:28, 28 August 2022 by JasLee24 (Talk | contribs)


human intracellular PD-1

This part is the intracellular domain of human programmed death-1 (PD-1). Expressed on effector T cells, PD-1 acts as an inhibitory receptor regulating T cell effector functions. When programmed death-ligand 1 (PD-L1) and PD-L2 on the antigen-presenting cells (APCs) bind to PD-1, the intracellular domain of PD-1 will recruit phosphatases including SHP2 to downregulate some signaling pathways (e.g., PI3K-AKT pathway). Consequently, the effector T cell activity is inhibited [1].

Sequence and Features


Assembly Compatibility:
  • 10
    COMPATIBLE WITH RFC[10]
  • 12
    COMPATIBLE WITH RFC[12]
  • 21
    COMPATIBLE WITH RFC[21]
  • 23
    COMPATIBLE WITH RFC[23]
  • 25
    COMPATIBLE WITH RFC[25]
  • 1000
    COMPATIBLE WITH RFC[1000]


[edit]
Categories
Parameters
biologyHuman