Protein_Domain

Part:BBa_K4165064

Designed by: Esraa Elmligy   Group: iGEM22_CU_Egypt   (2022-09-30)
Revision as of 10:01, 8 October 2022 by Engy99 (Talk | contribs)


GGGGSGG Linker

A flexible 7 aa Glycine-Serine linker


Usage and Biology

A flexible linker with G and S aa residues with variable lengths. According to our project, 3 flexible linker required one for our clamps for binding of Tau or amyloid beta with our binding peptides. Second one for flexible linking between clamps and HTRA1 binding peptide. last one for binding our HTRA1 binding peptide with PDZ domain of our protease HTRA1. our linker with length [7 aa GGSGGGG ] was calculated by our team for testing how it would affect interaction of our mentioned parts with each other using Pymol Software.

Sequence and Features


Assembly Compatibility:
  • 10
    COMPATIBLE WITH RFC[10]
  • 12
    COMPATIBLE WITH RFC[12]
  • 21
    COMPATIBLE WITH RFC[21]
  • 23
    COMPATIBLE WITH RFC[23]
  • 25
    COMPATIBLE WITH RFC[25]
  • 1000
    COMPATIBLE WITH RFC[1000]

References

1- Yuan, S., Chan, H. S., & Hu, Z. (2017). Using pymol as a platform for computational drug design. WIREs Computational Molecular Science, 7(2). doi:10.1002/wcms.1298


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